P-105: Genetic Variation of Kinase Insert Domain-Containing Receptor Gene and Its Association with Recurrent Spontaneous Abortion
نویسندگان
چکیده مقاله:
Background Recurrent spontaneous abortion has been defined two or more consecutive miscarriages at 20 weeks pregnancy and one of diseases that can lead to physical, psychological and economical for the individual problems. Recently number of polymorphisms in several genes was examined for association analyses in pregnant women which related to endanger the life of the fetus. In present study we investigated allele frequency of SNP in Kinase insert Domain Receptor (KDR) gene in women with recurrent miscarriage. MaterialsAndMethods One hundred women with recurrent spontaneous abortion of the fetus with at least 2 or more miscarriages before 20 weeks and without anatomical problems of the uterus, cytogenetic, hormonal problems as patients and 100 women with no history of abortion and with having had successful birth were chosen as controls. For polymorphism analysis of functional SNP rs1870377, PCR-RFLP was performed by using the restriction enzymes AluI and digested products were visualized on 12% acrylamide gel respectively. The differences between allele frequency in two grouped were calculated by chi square test with P value
منابع مشابه
association of kinase insert domain-containing receptor (kdr) gene polymorphism/ haplotypes with recurrent spontaneous abortion and genetic structure
background: recurrent spontaneous abortion is one of the diseases that can lead to physical, psychological, and, economical problems for both individuals and society. recently a few numbers of genetic polymorphisms in kinase insert domain-containing receptor (kdr) gene are examined that can endanger the life of the fetus in pregnant women. objective: the risk of kdr gene polymorphisms was inves...
متن کاملAssociation of kinase insert domain-containing receptor (KDR) gene polymorphism/ haplotypes with recurrent spontaneous abortion and genetic structure
BACKGROUND Recurrent spontaneous abortion is one of the diseases that can lead to physical, psychological, and, economical problems for both individuals and society. Recently a few numbers of genetic polymorphisms in kinase insert domain-containing receptor (KDR) gene are examined that can endanger the life of the fetus in pregnant women. OBJECTIVE The risk of KDR gene polymorphisms was inves...
متن کاملP-126: VEGFA Gene Polymorphisms and Its Association with Recurrent Spontaneous Abortion
Background Spontaneous abortion has been defined as two or more consecutive miscarriages at 20 weeks pregnancy. Vascular endothelial growth factor (VEGF) plays a main role in fetal and placental angiogenesis which secretes from different cells like endometrium and placenta.The objective of this study was to investigate of association of VEGFA gene polymorphisms and recurrent spontaneous abortio...
متن کاملP-157: TLR5 Gene Expression in Endometrium of Women with Unexplained Recurrent Spontaneous Abortion
Background: Recurrent spontaneous abortion (RSA) is usually defined as three or more consecutive pregnancy losses before 20th week of gestation. Although different factors are considered as etiology of RSA but in some cases, despite of extensive work up, the cause of RSA remains unknown which called unexplained RSA. Immunological factors are suggested as etiological factors of unexplained RSA. ...
متن کاملP-212: Association between Polymorphisms of CTLA-4 Gene and Unexplained Recurrent Spontaneous Abortion in An Iranian Population
Background: Unexplained recurrent spontaneous abortion (URSA) has been suggested being associated with the failure of fetal-maternal immunologic tolerance in which the regulatory T lymphocytes (Tregs) play a crucial role. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is expressed transiently on activated T cells and constitutively on Tregs. CTLA-4 interacts with the B7 cell surface molec...
متن کاملEvaluation of the Association between the C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexpla...
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عنوان ژورنال
دوره 9 شماره 2
صفحات 87- 87
تاریخ انتشار 2015-09-01
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